Author Correction: Affinity-coupled CCL22 promotes positive selection in germinal centres
نویسندگان
چکیده
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03384-8.
منابع مشابه
An analysis of B cell selection mechanisms in germinal centres
Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen. The mechanism underlying B cell selection has not yet been defined. By employing an agent-based model, we show that for physiologically reasona...
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The role of apoptosis in affinity maturation was investigated by determining the affinity of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and serum antibody in transgenic mice that overexpress a suppressor of apoptosis, Bcl-xL, in the B cell compartment. Although transgenic animals briefly expressed higher numbers of splenic AFCs after immunization, the bcl-xL tra...
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ژورنال
عنوان ژورنال: Nature
سال: 2021
ISSN: ['1476-4687', '0028-0836']
DOI: https://doi.org/10.1038/s41586-021-03384-8